Fibrinogen is a promising biomarker for chronic obstructive pulmonary disease: evidence from a meta-analysis.

ABSTRACT: Some studies have reported association of circulating fibrinogen with the risk of chronic obstructive pulmonary disease (COPD), and the results are conflicting. To yield more information, we aimed to test the hypothesis that circulating fibrinogen is a promising biomarker for COPD by a meta-analysis. Data extraction and quality assessment were independently completed by two authors. Effect-size estimates are expressed as weighted mean difference (WMD) with 95% confidence interval (95% CI). Forty-five articles involving 5586/18604 COPD patients/controls were incorporated. Overall analyses revealed significantly higher concentrations of circulating fibrinogen in COPD patients than in controls (WMD: 84.67 mg/dl; 95% CI: 64.24-105.10). Subgroup analyses by COPD course showed that the degree of

SUBMITTER: Zhou B 

PROVIDER: S-EPMC7383837 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature