Urinary sulfate excretion and risk of late graft failure in renal transplant recipients - a prospective cohort study.

ABSTRACT: Hydrogen sulfide (H₂ S), produced from metabolism of dietary sulfur-containing amino acids, is allegedly a renoprotective compound. Twenty-four-hour urinary sulfate excretion (USE) may reflect H₂ S bioavailability. We aimed to investigate the association of USE with graft failure in a large prospective cohort of renal transplant recipients (RTR). We included 704 stable RTR, recruited at least 1 year after transplantation. We applied log-rank testing and Cox regression analyses to study association of USE, measured from baseline 24 h urine samples, with graft failure. Median age was 55 [45-63] years (57% male, eGFR was 45 ± 19 ml/min/1.73 m² ). Median USE was 17.1 [13.1-21.1] mmol/24 h. Over median follow-up of 5.3 [4.5-6.0] years, 84 RTR experienced graft f

SUBMITTER: Said MY 

PROVIDER: S-EPMC7383851 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature