A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.

ABSTRACT: Current HIV vaccines are only partially efficacious, presenting an opportunity to identify correlates of protection and, thereby, potential insight into mechanisms that prevent HIV acquisition. Two independent preclinical challenge studies in nonhuman primates (NHPs) previously showed partial efficacy of a mosaic adenovirus 26 (Ad26)-based HIV-1 vaccine candidate. To investigate the basis of this protection, we performed whole transcriptomics profiling by RNA sequencing (RNA-seq) in sorted lymphocytes from peripheral blood samples taken during these studies at different time points after vaccination but before challenge. We observed a transcriptional signature in B cells that associated with protection from acquisition of simian immunodeficiency virus (SIV) or the simian-human immunodefici

SUBMITTER: Ehrenberg PK 

PROVIDER: S-EPMC7383941 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature