Multinational Investigation of Fracture Risk with Antidepressant Use by Class, Drug, and Indication.

ABSTRACT:

Objectives

Antidepressants increase the risk of falls and fracture in older adults. However, risk estimates vary considerably even in comparable populations, limiting the usefulness of current evidence for clinical decision making. Our aim was to apply a common protocol to cohorts of older antidepressant users in multiple jurisdictions to estimate fracture risk associated with different antidepressant classes, drugs, doses, and potential treatment indications.

Design

Retrospective (2009-2014) cohort study.

Setting

Five jurisdictions in the United States, Canada, United Kingdom, and Taiwan.

Participants

Older antidepressant users-subjects were followed from first antidepressant prescription or dispensation to first fracture or until the end of follow-up.

Meas

SUBMITTER: Tamblyn R 

PROVIDER: S-EPMC7383967 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature