Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar-associated protein 4.

ABSTRACT:

Background

Alcoholic liver disease (ALD) is a public health concern that is the cause of half of all cirrhosis-related deaths. Early detection of fibrosis, ideally in the precirrhotic stage, is a key strategy for improving ALD outcomes and for preventing progression to cirrhosis. Previous studies identified the blood-borne marker human microfibrillar-associated protein 4 (MFAP4) as a biomarker for detection of hepatitis C virus (HCV)-related fibrosis.

Aim

To evaluate the diagnostic accuracy of MFAP4 to detect ALD-induced fibrosis.

Method

We performed a prospective, liver biopsy-controlled study involving 266 patients with prior or current alcohol overuse. Patients were split into a training and a validation cohort.

Results

MFAP4 was present in fibrotic hepatic

SUBMITTER: Madsen BS 

PROVIDER: S-EPMC7383987 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature