Chemical-induced craniofacial anomalies caused by disruption of neural crest cell development in a zebrafish model.

ABSTRACT:

Background

Craniofacial anomalies are among the most frequent birth defects worldwide, and are thought to be caused by gene-environment interactions. Genetically manipulated zebrafish simulate human diseases and provide great advantages for investigating the etiology and pathology of craniofacial anomalies. Although substantial advances have been made in understanding genetic factors causing craniofacial disorders, limited information about the etiology by which environmental factors, such as teratogens, induce craniofacial anomalies is available in zebrafish.

Results

Zebrafish embryos displayed craniofacial malformations after teratogen treatments. Further observations revealed characteristic disruption of chondrocyte number, shape and stacking. These findings suggested abe

SUBMITTER: Liu S 

PROVIDER: S-EPMC7384000 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature