Adipose tissue depot-specific intracellular and extracellular cues contributing to insulin resistance in obese individuals.

ABSTRACT: Adipose tissue dysregulation in obesity strongly influences systemic metabolic homeostasis and is often linked to insulin resistance (IR). However, the molecular mechanisms underlying adipose tissue dysfunction in obesity are not fully understood. Herein, a proteomic analysis of subcutaneous (SC) and omental (OM) fat from lean subjects and obese individuals with different degrees of insulin sensitivity was performed to identify adipose tissue biomarkers related to obesity-associated metabolic disease. Our results suggest that dysregulation of both adipose tissue extracellular matrix (ECM) organization and intracellular trafficking processes may be associated with IR in obesity. Thus, abnormal accumulation of the small leucine-rich proteoglycan, lumican, as observed in SC fat of IR obese in

SUBMITTER: Guzman-Ruiz R 

PROVIDER: S-EPMC7384030 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature