Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure.

ABSTRACT: The intestinal epithelium is perpetually renewed from a stem cell niche in the base of crypts to maintain a healthy bowel mucosa. Exit from this niche and maturation of epithelial cells requires tightly controlled gradients in BMP signalling, progressing from low BMP signalling at the crypt base to high signalling at the luminal surface. The BMP antagonist gremlin 1 (Grem1) is highly expressed by subepithelial myofibroblasts adjacent to the intestinal crypts but its role in regulating the stem cell niche and epithelial renewal in vivo has not been explored. To explore the effects of Grem1 loss in adulthood following normal growth and development, we bred mice (ROSA26CreER-Grem1 ^flx/flx ) in which Grem1 could be deleted by tamoxifen administration. While Grem1 remained intact, th

SUBMITTER: Rowan SC 

PROVIDER: S-EPMC7384058 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature