Clinical outcomes after first-line HIV treatment failure in South Africa: the next cascade of care.

ABSTRACT:

Introduction

There is limited literature on the appropriateness of viral load (VL) monitoring and management of detectable VL in public health settings in rural South Africa.

Methods

We analysed data captured in the electronic patient register from HIV-positive patients ≥ 15 years old initiating antiretroviral therapy (ART) in 17 public sector clinics in rural KwaZulu-Natal, during 2010-2016. We estimated the completion rate for VL monitoring at 6, 12, and 24 months. We described the cascade of care for those with any VL measurement ≥ 1000 HIV-1 RNA copies/mL after ≥ 20 weeks on ART, including the following proportions: (1) repeat VL within 6 months; (2) re-suppressed; (3) switched to second-line regimen.

Results

There were 29 384 individuals who initiated ART during

SUBMITTER: Iwuji CC 

PROVIDER: S-EPMC7384088 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature