Optimization of hepatitis C virus screening strategies by birth cohort in Italy.

ABSTRACT:

Background and aims

Cost-effective screening strategies are needed to make hepatitis C virus (HCV) elimination a reality. We determined if birth cohort screening is cost-effective in Italy.

Methods

A model was developed to quantify screening and healthcare costs associated with HCV. The model-estimated prevalence of undiagnosed HCV was used to calculate the antibody screens needed annually, with a €25 000 cost-effectiveness threshold. Outcomes were assessed under the status quo and a scenario that met the World Health Organization's targets for elimination of HCV. The elimination scenario was assessed under five screening strategies.

Results

A graduated birth cohort screening strategy (graduated screening 1: 1968-1987 birth cohorts, then expanding to 1948-1967 cohorts

SUBMITTER: Kondili LA 

PROVIDER: S-EPMC7384106 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature