Effects of tocolysis with nifedipine or atosiban on child outcome: follow-up of the APOSTEL III trial.

ABSTRACT:

Objective

To compare the long-term effects of tocolysis with nifedipine or atosiban on child outcome at age 2.5-5.5 years.

Design

The APOSTEL III trial was a multicentre randomised controlled trial that compared tocolysis with nifedipine or atosiban in 503 women with threatened preterm birth. Neonatal outcomes did not differ between both treatment arms, except for a higher incidence of intubation in the atosiban group.

Methods

Parents were asked to complete four questionnaires regarding neurodevelopment, executive function, behaviour problems and general health.

Main outcome measures

The main long-term outcome measure was a composite of abnormal development at the age of 2.5-5.5 years.

Results

Of the 426 women eligible for follow-up, 196 (46%) parents re

SUBMITTER: van Winden T 

PROVIDER: S-EPMC7384124 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature