N-Trifluoromethyl Hydrazines, Indoles and Their Derivatives.

ABSTRACT: Reported herein is the first efficient strategy to synthesize a broad range of unsymmetrical N-CF3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri- and tetra-substituted N-CF3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N-CF3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF3 )-NH2 to function as a directing group in C-H functionalization is also showcased.

SUBMITTER: Bouayad-Gervais S 

PROVIDER: S-EPMC7384184 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature