Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is the third most common cancer worldwide, accounting for 10% of the global cancer burden. Rectal cancer accounts for around 30% of CRC cases, and patients with resectable rectal cancer are often given preoperative radiotherapy (PRT) to reduce the rate of local recurrence. The human plasma proteome is an exceptionally complex proteome and ideal to study due to its ability to reflect the presence of diseases such as cancer and the ease of obtaining blood samples. Previous proteomic studies involving rectal cancer patients have mostly focused on the identification of proteins involved in resistance to radiotherapy.

Objective

The aim of this study was to investigate the overall effects of PRT on plasma protein expression in rectal cancer pat

SUBMITTER: Holm M 

PROVIDER: S-EPMC7384342 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature