Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations.

ABSTRACT: Metabotropic glutamate (mGlu) receptors are family C G protein-coupled receptors (GPCRs) that modulate neuronal excitability and synaptic transmission throughout the nervous system. Owing to recent advances in development of subtype-selective allosteric modulators of mGlu receptors, individual members of the mGlu receptor family have been proposed as targets for treating a variety of neurological and psychiatric disorders, including substance use disorders. In this chapter, we highlight preclinical evidence that allosteric modulators of mGlu receptors could be useful for reducing alcohol consumption and preventing relapse in alcohol use disorder (AUD). We begin with an overview of the preclinical models that are used to study mGlu receptor involvement in alcohol-related behaviors. Alcohol

SUBMITTER: Johnson KA 

PROVIDER: S-EPMC7384598 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature