OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling.

ABSTRACT: In this study, we propose a new open-source simulation platform that comprises computer-aided design and computer-aided engineering tools for highly automated evaluation of electric field distribution and neural activation during Deep Brain Stimulation (DBS). It will be shown how a Volume Conductor Model (VCM) is constructed and examined using Python-controlled algorithms for generation, discretization and adaptive mesh refinement of the computational domain, as well as for incorporation of heterogeneous and anisotropic properties of the tissue and allocation of neuron models. The utilization of the platform is facilitated by a collection of predefined input setups and quick visualization routines. The accuracy of a VCM, created and optimized by the platform, was estimated by comparison wi

SUBMITTER: Butenko K 

PROVIDER: S-EPMC7384674 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature