Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo.

ABSTRACT: Retinoblastoma (RB) is one of the most aggressive malignancies affecting infants and children. Platinum drugs are commonly used in the treatment of RB; however, their efficacy is often compromised by drug resistance and severe toxicity. The present study aimed to investigate and compare the toxicity and antitumor activity of the third‑generation platinum drugs, carboplatin and lobaplatin, in vitro and in vivo. The Y79 RB cell line was treated with carboplatin or lobaplatin in vitro and then used to establish xenografts in immunodeficient nude mice in vivo; the effects of pharmacological doses of these drugs were then assessed. High concentrations of carboplatin and lobaplatin markedly inhibited Y79 RB cell proliferation in vitro. In addition, the lobaplatin group exhibited higher proportio

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC7384850 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature