High-Resolution Dynamic ³¹P-MR Spectroscopic Imaging for Mapping Mitochondrial Function.

ABSTRACT:

Objective

To enable non-invasive dynamic metabolic mapping in rodent model studies of mitochondrial function using ³¹P-MR spectroscopic imaging (MRSI).

Methods

We developed a novel method for high-resolution dynamic ³¹P-MRSI. The method synergistically integrates physics-based models of spectral structures, biochemical modeling of molecular dynamics, and subspace learning to capture spatiospectral variations. Fast data acquisition was achieved using rapid spiral trajectories and sparse sampling of (k, t, T)-space; image reconstruction was accomplished using a low-rank tensor-based framework.

Results

The proposed method provided high-resolution dynamic metabolic mapping in rat hindlimb at spatial and temporal resolutions of 4[Formula: see text]2 m

SUBMITTER: Clifford B 

PROVIDER: S-EPMC7384926 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature