Versatile simulations of admixture and accurate local ancestry inference with mixnmatch and ancestryinfer.

ABSTRACT: It has become clear that hybridization between species is much more common than previously recognized. As a result, we now know that the genomes of many modern species, including our own, are a patchwork of regions derived from past hybridization events. Increasingly researchers are interested in disentangling which regions of the genome originated from each parental species using local ancestry inference methods. Due to the diverse effects of admixture, this interest is shared across disparate fields, from human genetics to research in ecology and evolutionary biology. However, local ancestry inference methods are sensitive to a range of biological and technical parameters which can impact accuracy. Here we present paired simulation and ancestry inference pipelines, mixnmatch and ancestry

SUBMITTER: Schumer M 

PROVIDER: S-EPMC7384932 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature