Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome.

ABSTRACT: Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe alterations have been found in samples from epilepsy patients and in the hippocampal neurogenic niche in mouse models of epilepsy. Reactive-like and gliogenic NSCs plus aberrant newborn neurons with altered migration, morphology, and functional properties are induced by seizures in experimental models of temporal lobe epilepsy. Hippocampal neurogenesis participates in memory and learning and in the control of anxiety and stress. It has been therefore hypothesized that part of the cognitive symptoms associated with epilepsy could be promoted by impaired hippocampal neuroge

SUBMITTER: Martin-Suarez S 

PROVIDER: S-EPMC7385077 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature