Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.

ABSTRACT: Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases. Therefore, it is of fundamental importance to understand how memory T cells are generated. However, the molecular mechanisms governing memory Th cell generation remain incompletely understood. Here, we identified CD30 as a molecule heterogeneously expressed on effector Th1 and Th17 cells, and CD30^hi effector Th1 and Th17 cells preferentially generated memory Th1 and Th17 cells. We found that CD30 mediated signal induced Transglutaminase-2 (TG2) expression, and that the TG2 expression in effector Th cells is essential for memory Th cell generation. In fact, Cd30-deficiency resulted in the impaired generati

SUBMITTER: Suzuki AS 

PROVIDER: S-EPMC7385138 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature