Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma.

ABSTRACT: Glucocorticoids (GC) are a controversial yet commonly used intervention in the clinical management of acute inflammatory conditions, including sepsis or traumatic injury. In the context of major trauma such as surgery, concerns have been raised regarding adverse effects from GC, thereby necessitating a better understanding of how GCs modulate the immune response. Here we report the results of a randomized controlled trial (NCT02542592) in which we employ a high-dimensional mass cytometry approach to characterize innate and adaptive cell signaling dynamics after a major surgery (primary outcome) in patients treated with placebo or methylprednisolone (MP). A robust, unsupervised bootstrap clustering of immune cell subsets coupled with random forest analysis shows profound (AUC = 0.92, p-valu

SUBMITTER: Ganio EA 

PROVIDER: S-EPMC7385146 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature