Friend or Foe: Prognostic and Immunotherapy Roles of BTLA in Colorectal Cancer.

ABSTRACT:

Background

B and T lymphocyte attenuator (BTLA) is a co-signaling protein belonging to the CD28 immunoglobulin superfamily. However, the role of BTLA in prognosis and immunotherapy of colorectal cancer (CRC) remains unclear.

Methods

We evaluated the expression of BTLA via the Oncomine and the cancer genome atlas (TCGA) database. We research the outcome among different BTLA expression patients by Kaplan-Meier curve. We used the Chi-Squared test and Cox regression analysis to identify potential risk factors. Besides, the correlations between BTLA and cancer immune infiltration were investigated via CIBERSORT.

Results

Various cohorts showed that BTLA expression was lower in CRC compared to corresponding normal tissue. Moreover, low BTLA expression was correlated with poo

SUBMITTER: Song J 

PROVIDER: S-EPMC7385242 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature