Modification of the Marmarou model in developing countries.

ABSTRACT:

Introduction

Head injury is an injury or wound of the brain tissue due to external forces; it can cause a decrease or change in the status of consciousness. Many head injury models have used mice as experimental animals; the Marmarou model is the most famous and the most widely-used diffuse brain injury model. In this study, we slightly modified the Marmarou model. The purpose of this study is to help researchers examining head injuries in mice, especially those in developing countries who have limited facilities and infrastructure.

Methods

This experimental research uses animals models (Rattus novergicus, strain Sprague Dawley) that fit several criteria, including male, aged 10-12 weeks, and body weight of 200-300 g. This study involves a slight modification on the t

SUBMITTER: Nasution RA 

PROVIDER: S-EPMC7385274 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature