Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of I _K(M) or I _K(DR) and in the Stimulation of I _MEP.

ABSTRACT: Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ion currents remains largely uncertain. In this study, we hence intended to explore the possible perturbations of RDV on ionic currents endogenous in pituitary GH₃ cells and Jurkat T-lymphocytes. The whole-cell current recordings of ours disclosed that upon membrane depolarization in GH₃ cells the exposure to RDV concentration-dependently depressed the peak or late components of I _K(DR) elicitation with effective IC₅₀ values of 10.1 or 2.8 μM, respectively; meanwhile, the value of dissociation constant o

SUBMITTER: Chang WT 

PROVIDER: S-EPMC7385287 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature