FAM111B enhances proliferation of KRAS-driven lung adenocarcinoma by degrading p16.

ABSTRACT: Lung cancer is a common type of cancer that represents a health problem worldwide; lung adenocarcinoma (LUAD) is a major subtype of lung cancer. Although several treatments for LUAD have been developed, the mortality rate remains high because of uncontrollable progression. Further biological and clinicopathological studies are therefore needed. Here, we investigated the role of family with sequence similarity 111 member B (FAM111B), which is highly expressed in papillary-predominant LUAD; however, its role in cancer is unclear. An immunohistochemical analysis confirmed that papillary-predominant adenocarcinomas exhibited higher expression of FAM111B, compared with lepidic-predominant adenocarcinomas. Additionally, FAM111B expression was significantly correlated with clinical progression. I

SUBMITTER: Kawasaki K 

PROVIDER: S-EPMC7385341 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature