Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.

ABSTRACT:

Background

Light to moderate alcohol consumption has been variably associated with lower or higher risk of dementia, but effects on Alzheimer's disease pathology are less clear.

Objective

We determined whether late-life alcohol consumption was associated with Alzheimer's disease pathology among older adults.

Methods

We assessed the associations of alcohol consumption self-reported in 2000-2002 with brain amyloid-β deposition on PET scans, and white matter lesion and hippocampal volume on MRIs measured 7-9 years later in 189 participants of the Ginkgo Evaluation of Memory Study (age 75-87 years at baseline) who were free of clinical dementia, using multivariable-adjusted and inverse probability-weighted robust linear regression models.

Results

Alcohol consumptio

SUBMITTER: Koch M 

PROVIDER: S-EPMC7385407 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature