Multi-trait multi-locus SEM model discriminates SNPs of different effects.

ABSTRACT:

Background

There is a plethora of methods for genome-wide association studies. However, only a few of them may be classified as multi-trait and multi-locus, i.e. consider the influence of multiple genetic variants to several correlated phenotypes.

Results

We propose a multi-trait multi-locus model which employs structural equation modeling (SEM) to describe complex associations between SNPs and traits - multi-trait multi-locus SEM (mtmlSEM). The structure of our model makes it possible to discriminate pleiotropic and single-trait SNPs of direct and indirect effect. We also propose an automatic procedure to construct the model using factor analysis and the maximum likelihood method. For estimating a large number of parameters in the model, we performed Bayesian inference and

SUBMITTER: Igolkina AA 

PROVIDER: S-EPMC7385891 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature