Efficient mutation screening for cervical cancers from circulating tumor DNA in blood.

ABSTRACT:

Background

Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasive method for testing and monitoring cancer markers. However, tumor-specific alterations in ctDNA have not been extensively investigated or compared to other circulating biomarkers in the diagnosis and monitoring of the CC. Therfore, Next-generation sequencing (NGS) analysis with blood samples can be a new approach for highly accurate diagnosis and monitoring of the CC.

Method

Using a bioinformatics approach, we designed a panel of 24 genes associated with CC to detect and characterize patterns of somatic single-nucleotide variations, indels, and copy number v

SUBMITTER: Lee SY 

PROVIDER: S-EPMC7385901 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature