Associations between polymorphisms in IL-10 gene and the risk of viral hepatitis: a meta-analysis.

ABSTRACT:

Background

The relationships between polymorphisms in interleukin-10 (IL-10) gene and the risk of viral hepatitis remain inconclusive. Therefore, the authors conducted so far the very first meta-analysis to robustly assess the relationships between polymorphisms in IL-10 gene and the risk of viral hepatitis by integrating the results of previous works.

Methods

Medline, Embase, Wanfang, VIP and CNKI were searched throughly for eligible studies, and 76 genetic association studies were finally included in this meta-analysis.

Results

We noticed that rs1800871 (- 819 C/T), rs1800872 (- 592 C/A) and rs1800896 (- 1082 G/A) polymorphisms were all significantly associated with the risk of viral hepatitis in Asians, whereas only rs1800896 (- 1082 G/A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7385948 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature