Genetically Modified T-Cell Therapy for Osteosarcoma: Into the Roaring 2020s.

ABSTRACT: T-cell immunotherapy may offer an approach to improve outcomes for patients with osteosarcoma who fail current therapies. In addition, it has the potential to reduce treatment-related complications for all patients. Generating tumor-specific T cells with conventional antigen-presenting cells ex vivo is time-consuming and often results in T-cell products with a low frequency of tumor-specific T cells. Furthermore, the generated T cells remain sensitive to the immunosuppressive tumor microenvironment. Genetic modification of T cells is one strategy to overcome these limitations. For example, T cells can be genetically modified to render them antigen specific, resistant to inhibitory factors, or increase their ability to home to tumor sites. Most genetic modification strategies have only been

SUBMITTER: DeRenzo C 

PROVIDER: S-EPMC7385999 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature