Risk of Gastrointestinal Bleeding Increases With Combinations of Antithrombotic Agents and Patient Age.

ABSTRACT:

Background & aims

The safety of different antithrombotic strategies for patients with 1 or more indication for antithrombotic drugs has not been determined. We investigated the risk and time frame for gastrointestinal bleeding (GIB) in patients prescribed different antithrombotic regimens. We proposed that risk would increase over time and with combination regimens, especially among elderly patients.

Methods

We performed a retrospective analysis of nationwide claims data from privately insured and Medicare Advantage enrollees who received anticoagulant and/or antiplatelet agents from October 1, 2010, through May 31, 2017. Patients were stratified by their prescriptions (anticoagulant alone, antiplatelet alone, or a combination) and by their primary diagnosis (atrial fibrilla

SUBMITTER: Abraham NS 

PROVIDER: S-EPMC7386161 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature