Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma.

ABSTRACT:

Background

Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels of 25-hydroxyvitamin D (25(OH)D), atopy, asthma and asthma severity in teenagers from Northeast Brazil.

Methods

This is a cross sectional study nested in a cohort population of asthma. 25(OH)D was quantified from 968 of 11-17 years old individuals by ELISA. Asthma diagnosis was obtained by using the ISAAC Phase III questionnaire. Specific IgE was determined by ImmunoCAP; genotyping was performed using the 2.5 HumanOmni Biochip from Illumina. Statistical analyses were performed in PLINK 1.07 and SPSS 22.1.

Results

After quality control, 104 Single Nucle

SUBMITTER: Galvao AA 

PROVIDER: S-EPMC7386242 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature