Identification of injury and shock driven effects on ex vivo platelet aggregometry: A cautionary tale of phenotyping.

ABSTRACT:

Background

Platelet behavior in trauma-induced coagulopathy is poorly understood. Injured patients have impaired platelet aggregation (dysfunction) in ex vivo agonist-stimulated platelet aggregometry (PA). However, PA assumes that platelets are inactivated before ex vivo stimulated aggregation, which may be altered by injury. We hypothesized that following trauma, platelet aggregation (area under the curve) is decreased regardless of injury burden, but that (1) minor injury is associated with an increased baseline electrical impedance, characteristic of a functional platelet phenotype (platelets that activate in response to injury), and that (2) severe injury is not associated with an increased baseline electrical impedance, characteristic of a dysfunctional phenotype (platelets th

SUBMITTER: Starr NE 

PROVIDER: S-EPMC7386285 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature