Network perturbation analysis in human bronchial epithelial cells following SARS-CoV2 infection.

ABSTRACT:

Background

SARS-CoV2, the agent responsible for the current pandemic, is also causing respiratory distress syndrome (RDS), hyperinflammation and high mortality. It is critical to dissect the pathogenetic mechanisms in order to reach a targeted therapeutic approach.

Methods

In the present investigation, we evaluated the effects of SARS-CoV₂ on human bronchial epithelial cells (HBEC). We used RNA-seq datasets available online for identifying SARS-CoV₂ potential genes target on human bronchial epithelial cells. RNA expression levels and potential cellular gene pathways have been analyzed. In order to identify possible common strategies among the main pandemic viruses, such as SARS-CoV₂, SARS-CoV1, MERS-CoV, and H1N1, we carried out a hypergeomet

SUBMITTER: Nunnari G 

PROVIDER: S-EPMC7386311 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature