Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships.

ABSTRACT: There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-person and within-person components to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black, Mage = 16.1 years) with at least three blood draws and a total of 394 follow-up observations. Multi-level modeling indicated that the within-person effect of tumor necrosis factor alpha (TNF-α) predicted change in total depressive symptoms, suggesting a potential causal relationship. There were no significant within-person effects of total depressive symptoms on change in biomarkers. Exploratory analyses

SUBMITTER: Moriarity DP 

PROVIDER: S-EPMC7386405 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature