Counteranions in the Stimulation Solution Alter the Dynamics of Exocytosis Consistent with the Hofmeister Series.

ABSTRACT: We show that the Hofmeister series of ions can be used to explain the cellular changes in exocytosis observed by single-cell amperometry for different counteranions. The formation, expansion, and closing of the membrane fusion pore during exocytosis was found to be strongly dependent on the counteranion species in solution. With stimulation of chaotropic anions (e.g., ClO₄^-), the expansion and closing time of the fusion pore are longer, suggesting chaotropes can extend the duration of exocytosis compared with kosmotropic anions (e.g., Cl^-). At a concentration of 30 mM, the two parameters (e.g., t_1/2 and t_fall) that define the duration of exocytosis vary with the Hofmeister series (Cl^- < Br^- < NO

SUBMITTER: He X 

PROVIDER: S-EPMC7386575 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature