Vitamin D supplementation for sickle cell disease.
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ABSTRACT:
SUBMITTER: Soe HHK
PROVIDER: S-EPMC7386793 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Vitamin D supplementation for sickle cell disease.
Soe Htoo Htoo Kyaw HHK Abas Adinegara Bl AB Than Nan Nitra NN Ni Han H Singh Jaspal J Said Abdul Razzak Bin Mohd ARBM Osunkwo Ifeyinwa I
The Cochrane database of systematic reviews 20200528
<h4>Background</h4>Sickle cell disease (SCD) is a genetic chronic haemolytic and pro-inflammatory disorder. With increased catabolism and deficits in energy and nutrient intake, individuals with SCD suffer multiple macro- and micro-nutritional deficiencies, including vitamin D deficiency. This is an update of a previous review.<h4>Objectives</h4>To investigate the effects of vitamin D supplementation in children and adults with SCD and to compare different dose regimens. To determine the effects ...[more]
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Project description:Vitamin D deficiency (VDD), 25-OHD levels <20 ng/ml, is prevalent among patients with sickle cell disease (SCD) and is linked to acute and chronic pain and bone fracture in this population. There is limited literature regarding VDD-associated risk factors for SCD. We examined potential clinical and genomic parameters associated with VDD in 335 adults with SCD in a cross-sectional study. VDD was present in 65% of adult SCD patients, and 25-OHD levels independently and positively correlated with older age (P < 0·001) and vitamin D supplementation (P < 0·001). 25-OHD levels were higher in SCD patients over 40 years of age compared to the general African-American population. Both lower 25-OHD levels and increased pain frequency were associated with increased expression of SLC6A5 encoding glycine transporter-2 (GlyT2), a protein involved in neuronal pain pathways. Lower 25-OHD levels were also associated with increased expression of CYP3A4, and with decreased expression of GC (also termed DBP) and VDR, three genes involved in vitamin D metabolism. We conclude that vitamin D supplementation should be an almost universal feature of the care of young adults with SCD, and that further research is warranted into genomic factors that regulate vitamin D metabolism in SCD.
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