Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women.

ABSTRACT:

Objective

Osteoporosis, the most prevalent bone disorder in humans, is a global public health issue and its relationship with menopause is well-established. The interaction between menopause and genes on osteoporosis risk is, however, yet to be fully elucidated. We assessed the association between menopause and osteoporosis in relation to the SOX6 rs297325 variant in Taiwanese women.

Methods

There were 7,581 female participants, aged 30 to 70 years old. Information on SOX6 rs297325 and menopause were obtained from the Taiwan Biobank Database while that on osteoporosis was obtained from the National Health Insurance Research Database.

Results

Menopause but not SOX6 rs297325 was significantly associated with a higher risk of osteoporosis (odds ratio [OR] = 1.48; 95% con

SUBMITTER: Hsu TL 

PROVIDER: S-EPMC7386873 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature