Cost-Effectiveness of a Small Intrapericardial Centrifugal Left Ventricular Assist Device.

ABSTRACT: There is limited data on the cost-effectiveness of continuous-flow left ventricular assist devices (LVAD) in the United States particularly for the bridge-to-transplant indication. Our objective is to study the cost-effectiveness of a small intrapericardial centrifugal LVAD compared with medical management (MM) and subsequent heart transplantation using the respective clinical trial data. We developed a Markov economic framework. Clinical inputs for the LVAD arm were based on prospective trials employing the HeartWare centrifugal-flow ventricular assist device system. To better assess survival in the MM arm, and in the absence of contemporary trials randomizing patients to LVAD and MM, estimates from the Seattle Heart Failure Model were used. Costs inputs were calculated based on Medicare

SUBMITTER: Silvestry SC 

PROVIDER: S-EPMC7386874 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature