Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

ABSTRACT:

Rationale & objective

Traditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex.

Study design

Prospective cohort study.

Setting & participants

Children with mild-to-moderate CKD enrolled in the Chronic Kidney Disease in Children (CKiD) Study at 49 pediatric nephrology centers across North America.

Exposure

Age- and sex-specific body mass index (BMI) z score.

Outcome

Age- and sex-specific left ventricular mass index (LVMI) z score and left ventricular hypertrophy (LVH).

Analytical approach

Longitudinal analyses using mi

SUBMITTER: Brady TM 

PROVIDER: S-EPMC7387195 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature