Exploring the potential of laser desorption ionisation time-of-flight mass spectrometry to analyse organic capping agents on inorganic nanoparticle surfaces.

ABSTRACT: Analytical techniques are in high demand for the determination of organic capping agents on surfaces of metallic nanoparticles (NPs) such as gold (Au) and silver (Ag). In this study, the potential of laser desorption ionisation time-of-flight mass spectrometry (LDI-ToF-MS) as a technique fit for this purpose is demonstrated. First, a collection of reference spectra of most commonly used organic capping agents, including small molecules and polymers was established. Second, the robustness of the method was tested towards parameters like NP core material and NP size. In a third step, the quantitative capabilities of LDI-ToF-MS were determined. Finally, the potential to detect chemical alterations of the organic capping agent was evaluated. LDI-ToF-MS is able to detect capping agents ranging

SUBMITTER: Giannopoulos K 

PROVIDER: S-EPMC7387369 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature