Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed in RA patients. For instance, new-onset untreated RA (NORA) is associated with the underrepresentation of the Clostridium cluster XIVa, including Lachnospiraceae, which are major butyrate producers, although the pathological relevance has remained obscure. Follicular regulatory T (T_FR) cells play critical regulatory roles in the pathogenesis of autoimmune diseases, including RA. Reduced number of circulating T_FR cells has been associated with the elevation of autoantibodies and disease severity in RA. However, the contribution of commensal microbe-derived buty

SUBMITTER: Takahashi D 

PROVIDER: S-EPMC7387783 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature