Ontology highlight
ABSTRACT:
SUBMITTER: Dong L
PROVIDER: S-EPMC7387830 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Dong Ling L Yu Le L Li Hui H Shi Lei L Luo Zhong Z Zhao Huakan H Liu Zhaojian Z Yin Guobing G Yan Xiaohua X Lin Zhenghong Z
iScience 20200709 8
Ubiquitin specific protease 39 (USP39), an ortholog of Sad1p in yeast, is essential for spliceosome assembly during pre-mRNA splicing in human. Although it is known that USP39 is upregulated and plays an oncogenic role in hepatocellular carcinoma (HCC), the underlying mechanism remains unknown. The results of this study demonstrated that USP39 can be acetylated by the histone acetyltransferase MYST1, which is required for its proteasome-mediated degradation by Von Hippel-Lindau protein. In HCC c ...[more]