Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin.

ABSTRACT: Air pollution containing particulate matter (PM) less than 2.5 μm (PM_2.5) plays an essential role in regulating hepatic disease. However, its molecular mechanism is not yet clear, lacking effective therapeutic strategies. In this study, we attempted to investigate the effects and mechanisms of PM_2.5 exposure on hepatic injury by the in vitro and in vivo experiments. At first, we found that PM_2.5 incubation led to a significant reduction of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), along with markedly reduced expression of different anti-oxidants. Notably, suppressor of IKKε (SIKE), known as a negative regulator of the interferon pathway, was decreased in PM_2.5-incubated cells, accompanied with increased activation of TANK-bindin

SUBMITTER: Ge C 

PROVIDER: S-EPMC7387847 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature