Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status.

ABSTRACT: Administration of vaccines during pregnancy provides maternal protection against infectious diseases. This protection is extended to their infants during the first months of life, as pathogen-specific antibodies formed in response to maternal vaccination are transferred across the placenta to the fetus. Notably, Tdap (tetanus-diphtheria-acellular pertussis) vaccination booster is routinely administered to pregnant women both to prevent neonatal tetanus and to ensure that infants have protective levels of pertussis antibodies until they are able to establish their own vaccine-induced levels. Whether infant protection through maternal immunization is merely due to an increase in maternal antibody levels or whether maternal immunization enhances the transfer of vaccine-specific antibodies is

SUBMITTER: Post AL 

PROVIDER: S-EPMC7388058 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature