Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass.

ABSTRACT:

Objectives

To determine the production of 9-hydroxyoctadecadienoic acid and 13-hydroxyoctadecadienoic acid during cardiopulmonary bypass in infants and children undergoing cardiac surgery, evaluate their relationship with increase in cell-free plasma hemoglobin, provide evidence of bioactivity through markers of inflammation and vasoactivity (WBC count, milrinone use, vasoactive-inotropic score), and examine their association with overall clinical burden (ICU/hospital length of stay and mechanical ventilation duration).

Design

Prospective observational study.

Setting

Twelve-bed cardiac ICU in a university-affiliated children's hospital.

Patients

Children were prospectively enrolled during their preoperative clinic appointments with the following criteria: great

SUBMITTER: Kim-Campbell N 

PROVIDER: S-EPMC7388063 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature