Acute Lengthening of Progenitor Mitosis Influences Progeny Fate during Cortical Development in vivo.

ABSTRACT:

Background/aims

Prenatal microcephaly is posited to arise from aberrant mitosis of neural progenitors, which disrupts both neuronal production and survival. Although microcephaly has both a genetic and environmental etiology, the mechanisms by which dysregulation of mitosis causes microcephaly are poorly understood. We previously discovered that prolonged mitosis of mouse neural progenitors, either ex vivo or in vitro, directly alters progeny cell fate, -resulting in precocious differentiation and apoptosis. This raises questions as to whether prolonged progenitor mitosis affects cell fate and neurogenesis in vivo, and what are the underlying mechanisms?

Methods/results

Towards addressing these knowledge gaps, we developed an in vivo model of mitotic delay. This uses pharmac

SUBMITTER: Mitchell-Dick A 

PROVIDER: S-EPMC7388066 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature