In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies.

ABSTRACT: Significance: Stem cell therapies are of interest for treating a variety of neurodegenerative diseases and injuries of the spinal cord. However, the lack of techniques for longitudinal monitoring of stem cell therapy progression is inhibiting clinical translation. Aim: The goal of this study is to demonstrate an intraoperative imaging approach to guide stem cell injection to the spinal cord in vivo. Results may ultimately support the development of an imaging tool that spans intra- or postoperative environments to guide therapy throughout treatment. Approach: Stem cells were labeled with Prussian blue nanocubes (PBNCs) to facilitate combined ultrasound and photoacoustic (US/PA) imaging to visualize stem cell injection and delivery to the spinal cord in vivo</

SUBMITTER: Kubelick KP 

PROVIDER: S-EPMC7388074 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature