Meta-analysis of the association between MALAT1 rs619586 A>G polymorphism and cancer risk.

ABSTRACT:

Objective

This study aimed to systematically assess the effect of the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA rs619586 polymorphism on cancer risk.

Methods

We conducted a literature search of the PubMed, Embase, and China National Knowledge Internet databases to identify relevant studies, and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the retrieved studies using RevMan software.

Results

Nine eligible studies including 5968 cases and 7439 controls were included in the meta-analysis. The pooled results showed that MALAT1 rs619586 polymorphism was significantly associated with cancer risk [(AG + GG) vs. AA: OR = 0.88; GG vs. (AG + AA): OR = 0.64; GG vs. AA: OR = 0.63; AG vs. AA:

SUBMITTER: Ni W 

PROVIDER: S-EPMC7388131 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature