A novel temporal identity window generates alternating Eve⁺/Nkx6⁺ motor neuron subtypes in a single progenitor lineage.

ABSTRACT:

Background

Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate "cardinal classes" of neurons that share a transcription factor identity and common morphology. In Drosophila, two cardinal classes are Even-skipped (Eve)⁺ motor neurons projecting to dorsal longitudinal muscles, and Nkx6⁺ motor neurons projecting to ventral oblique muscles. Cross-repressive interactions prevent stable double-positive motor neurons. The Drosophila neuroblast 7-1 (NB7-1) lineage uses a temporal transcription factor cascade to generate five distinct Eve⁺ motor neurons; the origin and development of Nkx6⁺ motor neurons rema

SUBMITTER: Seroka A 

PROVIDER: S-EPMC7388218 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature